This idea started in the previous episode with an interaction that began with the tired and worn statement of "It's not you, it's me..." which I'll admit to having used along with having heard - both of which don't discount the validity of the phrase when it's true.
The idea then evolved into a "conversation" in which the voice-bubble conveyed little else but other much-used commiserations that are offered during a break-up, with the absurd irony at the end of of this narrative being that it's the voice-bubble itself that's the second character in this two-person interaction, offering platitudes that the woman clearly does not want to hear. And why would she? Why would anyone? Even if it's something we all may have said. Even when it may be true.
That said, though, it is an unspoken understanding between the artist (myself) and the woman depicted in this that the voice-bubble is actually an arsehole. That might be explored in later tales of both the voice-bubble and the woman. Maybe. Who knows? Certainly not me. Not yet, anyway. *shrugs*